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| Div. Prof. | 20.03.2021 | Club San José | - | Atlético Palmaflor | 1:3 | ??? |
| Div. Prof. | 03.04.2021 | Club San José | - | Royal Pari | 0:3 | ??? |
| Div. Prof. | 24.04.2021 | Club San José | - | CD Guabirá | 0:1 | ??? |
| Div. Prof. | 08.05.2021 | Club San José | - | Bolívar | 0:5 | ??? |
| Div. Prof. | 17.07.2021 | Club San José | - | Real Tomayapo | 1:2 | ??? |
| Div. Prof. | 22.07.2021 | Club San José | - | Independiente Petrolero | 1:3 | ??? |
| Div. Prof. | 30.07.2021 | Club San José | - | Nacional Potosí | 0:4 | ??? |
| Div. Prof. | 07.08.2021 | Club San José | - | The Strongest | 0:1 | ??? |
| Div. Prof. | 21.08.2021 | Club San José | - | Always Ready | 0:4 | ??? |
| Div. Prof. | 17.09.2021 | Club San José | - | Real Potosí | 0:0 | ??? |
| Div. Prof. | 25.09.2021 | Club San José | - | Blooming | 1:2 | ??? |
| Div. Prof. | 22.10.2021 | Club San José | - | Club Aurora | 1:4 | ??? |
| Div. Prof. | 22.11.2021 | Club San José | - | Real Santa Cruz | 1:2 | ??? |
Bolivie