| 1. Journée | 25.07.2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Journée | 30.07.2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 3. Journée | 06.08.2021 | Metalist 1925 Kharkiv | - | Chernomorets Odessa | 3:2 | ||||
| 4. Journée | 13.08.2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 5. Journée | 20.08.2021 | Vorskla Poltava | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 6. Journée | 28.08.2021 | Metalist 1925 Kharkiv | - | SK Dnipro-1 | 1:2 | ||||
| 7. Journée | 11.09.2021 | Metalist 1925 Kharkiv | - | Dinamo Kiev | 0:2 | ||||
| 8. Journée | 19.09.2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | ||||
| 10. Journée | 03.10.2021 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 |  |
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| 11. Journée | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 12. Journée | 22.10.2021 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 | ||||
| 13. Journée | 31.10.2021 | Metalist 1925 Kharkiv | - | Zorya Lugansk | 1:6 | ||||
| 14. Journée | 05.11.2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 15. Journée | 22.11.2021 | NK Veres | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Journée | 04.12.2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 |
Ukraine