| 1. Journée | 08.08.2021 | Sporting San Miguelito | - | Alianza | 1:2 |  |
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| 2. Journée | 16.08.2021 | Plaza Amador | - | Sporting San Miguelito | 0:0 | ||||
| 3. Journée | 21.08.2021 | Sporting San Miguelito | - | Tauro FC | 1:0 | ||||
| 4. Journée | 30.08.2021 | Sporting San Miguelito | - | Deportivo del Este | 1:1 | ||||
| 5. Journée | 04.09.2021 | Árabe Unido | - | Sporting San Miguelito | 0:1 | |
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| 6. Journée | 12.09.2021 | Sporting San Miguelito | - | UD Universitario | 1:0 | ||||
| 7. Journée | 17.09.2021 | Independiente de La Chorrera | - | Sporting San Miguelito | 3:0 | ||||
| 8. Journée | 26.09.2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Journée | 03.10.2021 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 10. Journée | 10.10.2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
| 11. Journée | 17.10.2021 | Atlético Chiriquí | - | Sporting San Miguelito | 1:1 | |
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| 12. Journée | 23.10.2021 | Alianza | - | Sporting San Miguelito | 1:0 | ||||
| 13. Journée | 31.10.2021 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 14. Journée | 07.11.2021 | Tauro FC | - | Sporting San Miguelito | 1:0 | ||||
| 16. Journée | 20.11.2021 | Sporting San Miguelito | - | Árabe Unido | 1:2 |
Panama