| 13. Journée | 27.11.2020 | Real Santa Cruz | - | Club Aurora | 4:2 | ||||
| 14. Journée | 30.11.2020 | Real Santa Cruz | - | Blooming | 0:2 | ||||
| 15. Journée | 03.12.2020 | The Strongest | - | Real Santa Cruz | 4:2 | ||||
| 16. Journée | 07.12.2020 | Club San José | - | Real Santa Cruz | 4:1 | ||||
| 17. Journée | 09.12.2020 | Real Santa Cruz | - | Real Potosí | 3:1 | ||||
| 18. Journée | 12.12.2020 | Real Santa Cruz | - | Always Ready | 0:3 | ||||
| 19. Journée | 14.12.2020 | Real Santa Cruz | - | Jorge Wilstermann | 1:3 |  |
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| 20. Journée | 17.12.2020 | Oriente Petrolero | - | Real Santa Cruz | 3:2 | ||||
| 21. Journée | 19.12.2020 | Real Santa Cruz | - | Atlético Palmaflor | 2:1 | ||||
| 22. Journée | 22.12.2020 | Bolívar | - | Real Santa Cruz | 4:0 | ||||
| 23. Journée | 24.12.2020 | Real Santa Cruz | - | Royal Pari | 2:4 | ||||
| 24. Journée | 27.12.2020 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 25. Journée | 29.12.2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | |
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| 26. Journée | 31.12.2020 | Club Aurora | - | Real Santa Cruz | 1:1 | |
Bolivie