| 1. Journée | 08.08.2021 | Sporting San Miguelito | - | Alianza | 1:2 | ||||
| 2. Journée | 16.08.2021 | Plaza Amador | - | Sporting San Miguelito | 0:0 | ||||
| 3. Journée | 21.08.2021 | Sporting San Miguelito | - | Tauro FC | 1:0 | ||||
| 7. Journée | 17.09.2021 | Independiente de La Chorrera | - | Sporting San Miguelito | 3:0 | ||||
| 8. Journée | 26.09.2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Journée | 03.10.2021 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 10. Journée | 10.10.2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 |
Paraguay