| 20. Journée | 09.01.2022 | FC Nantes | - | AS Monaco | 0:0 | ||||
| 21. Journée | 16.01.2022 | AS Monaco | - | Clermont Foot 63 | 4:0 | ||||
| 22. Journée | 23.01.2022 | Montpellier HSC | - | AS Monaco | 3:2 |  |
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| 23. Journée | 05.02.2022 | AS Monaco | - | Olympique Lyonnais | 2:0 | ||||
| 24. Journée | 13.02.2022 | AS Monaco | - | FC Lorient | 0:0 | ||||
| 25. Journée | 20.02.2022 | Girondins Bordeaux | - | AS Monaco | 1:1 |  |
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| 26. Journée | 27.02.2022 | AS Monaco | - | Stade de Reims | 1:2 | ||||
| 27. Journée | 06.03.2022 | Olympique Marseille | - | AS Monaco | 0:1 | ||||
| 28. Journée | 13.03.2022 | RC Strasbourg | - | AS Monaco | 1:0 | ||||
| 30. Journée | 03.04.2022 | FC Metz | - | AS Monaco | 1:2 | ||||
| 31. Journée | 10.04.2022 | AS Monaco | - | ESTAC Troyes | 2:1 | ||||
| 32. Journée | 15.04.2022 | Stade Rennais | - | AS Monaco | 2:3 | |
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| 33. Journée | 20.04.2022 | AS Monaco | - | OGC Nice | 1:0 | |
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| 34. Journée | 23.04.2022 | AS Saint-Étienne | - | AS Monaco | 1:4 | ||||
| 36. Journée | 06.05.2022 | Lille OSC | - | AS Monaco | 1:2 | ||||
| 37. Journée | 14.05.2022 | AS Monaco | - | Stade Brestois 29 | 4:2 | ||||
| 38. Journée | 21.05.2022 | RC Lens | - | AS Monaco | 2:2 |
Brésil