| 1. Journée | 16.07.2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 |  |
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| 4. Journée | 30.07.2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 5. Journée | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 8. Journée | 24.08.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Journée | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 10. Journée | 03.09.2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Journée | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Journée | 17.09.2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Journée | 24.09.2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 14. Journée | 01.10.2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 | ||||
| 15. Journée | 08.10.2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 19. Journée | 29.10.2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
| 22. Journée | 24.11.2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 |
Argentine