| 1. Journée | 13.08.2021 | NK Sesvete | - | NK Osijek II | 1:4 | ||||
| 4. Journée | 10.09.2021 | NK Osijek II | - | NK Solin | 3:2 |  |
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| 5. Journée | 15.09.2021 | NK Dubrava | - | NK Osijek II | 3:0 | ||||
| 6. Journée | 19.09.2021 | NK Osijek II | - | NK Croatia Zmijavci | 1:2 | ||||
| 11. Journée | 12.11.2021 | NK Inter Zaprešić | - | NK Osijek II | 2:0 | ||||
| 13. Journée | 19.11.2021 | NK Kustošija | - | NK Osijek II | 0:0 | ||||
| 14. Journée | 27.11.2021 | NK Osijek II | - | NK Jarun | 0:0 | ||||
| 15. Journée | 05.12.2021 | NK BSK Bijelo Brdo | - | NK Osijek II | 0:2 | |
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| 19. Journée | 05.03.2022 | NK Solin | - | NK Osijek II | 0:0 | ||||
| 21. Journée | 20.03.2022 | NK Croatia Zmijavci | - | NK Osijek II | 1:0 | ||||
| 22. Journée | 04.04.2022 | NK Osijek II | - | HNK Orijent Rijeka | 1:0 | ||||
| 26. Journée | 02.05.2022 | NK Osijek II | - | NK Inter Zaprešić | 1:2 | ||||
| 30. Journée | 28.05.2022 | NK Osijek II | - | NK BSK Bijelo Brdo | 1:1 |
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