| 1. Journée | 28.08.2021 | Twente/Heracles [U21] | - | Almere City FC [U21] | 1:2 | ||||
| 2. Journée | 11.09.2021 | NEC Nijmegen [U21] | - | Twente/Heracles [U21] | 2:1 | ||||
| 3. Journée | 18.09.2021 | Twente/Heracles [U21] | - | NAC Breda [U21] | 5:2 | ||||
| 6. Journée | 16.10.2021 | Twente/Heracles [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 8. Journée | 30.10.2021 | ADO Den Haag [U21] | - | Twente/Heracles [U21] | 3:1 | ||||
| 11. Journée | 04.12.2021 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 1:1 | ||||
| 12. Journée | 12.02.2022 | Almere City FC [U21] | - | Twente/Heracles [U21] | 1:2 | ||||
| 13. Journée | 26.02.2022 | Twente/Heracles [U21] | - | sc Heerenveen [U21] | 1:1 |
Pays-Bas