| 3. Journée | 10.03.2025 | Los Angeles Galaxy | - | St. Louis City SC | 0:3 | ||||
| 6. Journée | 30.03.2025 | St. Louis City SC | - | Austin FC | 0:1 | ||||
| 8. Journée | 14.04.2025 | St. Louis City SC | - | Columbus Crew | 1:2 | ||||
| 9. Journée | 20.04.2025 | St. Louis City SC | - | Vancouver Whitecaps | 0:0 | ||||
| 10. Journée | 28.04.2025 | Los Angeles FC | - | St. Louis City SC | 2:2 | ||||
| 11. Journée | 04.05.2025 | Seattle Sounders | - | St. Louis City SC | 4:1 | ||||
| 12. Journée | 11.05.2025 | St. Louis City SC | - | San Diego FC | 1:2 |  |
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| 13. Journée | 15.05.2025 | St. Louis City SC | - | Sporting Kansas City | 2:2 | ||||
| 14. Journée | 18.05.2025 | Minnesota United FC | - | St. Louis City SC | 3:0 | |
Allemagne