| 1. Journée | 28.08.2021 | Twente/Heracles [U21] | - | Almere City FC [U21] | 1:2 | ||||
| 2. Journée | 11.09.2021 | NEC Nijmegen [U21] | - | Twente/Heracles [U21] | 2:1 | ||||
| 3. Journée | 18.09.2021 | Twente/Heracles [U21] | - | NAC Breda [U21] | 5:2 | ||||
| 4. Journée | 25.09.2021 | Feyenoord [U21] | - | Twente/Heracles [U21] | 2:0 | ||||
| 6. Journée | 16.10.2021 | Twente/Heracles [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 9. Journée | 06.11.2021 | Twente/Heracles [U21] | - | Feyenoord [U21] | 0:3 | ||||
| 10. Journée | 20.11.2021 | NAC Breda [U21] | - | Twente/Heracles [U21] | 3:1 | ||||
| 11. Journée | 04.12.2021 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 1:1 | ||||
| 14. Journée | 18.12.2021 | FC Groningen [U21] | - | Twente/Heracles [U21] | 6:1 | ||||
| 12. Journée | 12.02.2022 | Almere City FC [U21] | - | Twente/Heracles [U21] | 1:2 |  |
Pays-Bas