| 5. Journée | 28.08.2021 | Morecambe FC | - | Sheffield Wednesday | 1:0 | ||||
| 7. Journée | 11.09.2021 | Plymouth Argyle | - | Sheffield Wednesday | 3:0 | ||||
| 8. Journée | 18.09.2021 | Sheffield Wednesday | - | Shrewsbury Town | 1:1 | ||||
| 15. Journée | 23.10.2021 | Sheffield Wednesday | - | Lincoln City | 1:1 | ||||
| 16. Journée | 30.10.2021 | Cheltenham Town | - | Sheffield Wednesday | 2:2 | ||||
| 6. Journée | 02.11.2021 | Sheffield Wednesday | - | Sunderland AFC | 3:0 |  |
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| 17. Journée | 13.11.2021 | Sheffield Wednesday | - | Gillingham FC | 1:1 | ||||
| 18. Journée | 20.11.2021 | Accrington Stanley | - | Sheffield Wednesday | 2:3 | |
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| 19. Journée | 23.11.2021 | Sheffield Wednesday | - | Milton Keynes Dons | 2:1 | ||||
| 20. Journée | 27.11.2021 | Sheffield Wednesday | - | Wycombe Wanderers | 2:2 | ||||
| 22. Journée | 11.12.2021 | Crewe Alexandra | - | Sheffield Wednesday | 0:2 |  |
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| 25. Journée | 30.12.2021 | Sunderland AFC | - | Sheffield Wednesday | 5:0 | ||||
| 26. Journée | 02.01.2022 | Shrewsbury Town | - | Sheffield Wednesday | 1:0 |
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