| 1. Journée | 28.02.2022 | Seattle Sounders | - | Nashville SC | 0:1 | ||||
| 2. Journée | 06.03.2022 | Minnesota United FC | - | Nashville SC | 1:1 | ||||
| 2. Journée | 13.03.2022 | FC Dallas | - | Nashville SC | 2:0 | ||||
| 2. Journée | 20.03.2022 | Real Salt Lake | - | Nashville SC | 2:1 | ||||
| 6. Journée | 04.07.2022 | Nashville SC | - | Portland Timbers | 2:2 | ||||
| 6. Journée | 10.07.2022 | Charlotte FC | - | Nashville SC | 4:1 | ||||
| 6. Journée | 14.07.2022 | Nashville SC | - | Seattle Sounders | 1:0 | ||||
| 6. Journée | 18.07.2022 | Nashville SC | - | Los Angeles FC | 1:2 | ||||
| 6. Journée | 24.07.2022 | FC Cincinnati | - | Nashville SC | 1:1 |  |
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| 6. Journée | 31.07.2022 | Nashville SC | - | Vancouver Whitecaps | 1:1 | |
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| 7. Journée | 04.08.2022 | Portland Timbers | - | Nashville SC | 1:1 | |
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| 7. Journée | 07.08.2022 | Nashville SC | - | Toronto FC | 3:4 | |
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| 8. Journée | 04.09.2022 | Nashville SC | - | Austin FC | 3:0 | ||||
| 8. Journée | 10.09.2022 | Nashville SC | - | Los Angeles Galaxy | 1:1 | ||||
| 8. Journée | 18.09.2022 | Austin FC | - | Nashville SC | 1:1 | ||||
| 9. Journée | 03.10.2022 | Nashville SC | - | Houston Dynamo | 1:2 | |
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| 9. Journée | 09.10.2022 | Los Angeles FC | - | Nashville SC | 0:1 | |
Canada