| 1. Journée | 23.02.2025 | Columbus Crew | - | Chicago Fire | 4:2 | ||||
| 2. Journée | 02.03.2025 | New England Revolution | - | Columbus Crew | 0:1 | ||||
| 6. Journée | 30.03.2025 | D.C. United | - | Columbus Crew | 1:2 | ||||
| 7. Journée | 06.04.2025 | Columbus Crew | - | CF Montréal | 2:1 | ||||
| 8. Journée | 14.04.2025 | St. Louis City SC | - | Columbus Crew | 1:2 |  |
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| 9. Journée | 19.04.2025 | Columbus Crew | - | Inter Miami CF | 0:1 | ||||
| 10. Journée | 27.04.2025 | Columbus Crew | - | San Jose Earthquakes | 2:1 |  |
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| 11. Journée | 04.05.2025 | Columbus Crew | - | Charlotte FC | 4:2 | ||||
| 12. Journée | 11.05.2025 | Philadelphia Union | - | Columbus Crew | 2:2 | ||||
| 13. Journée | 15.05.2025 | CF Montréal | - | Columbus Crew | 1:1 | ||||
| 14. Journée | 18.05.2025 | Columbus Crew | - | FC Cincinnati | 1:1 |
France