| 1. Journée | 16.07.2021 | Radnik Bijeljina | - | Leotar Trebinje | 0:1 | ||||
| 2. Journée | 25.07.2021 | Borac Banja Luka | - | Leotar Trebinje | 0:0 | ||||
| 3. Journée | 30.07.2021 | Sloboda Tuzla | - | Leotar Trebinje | 1:0 | ||||
| 4. Journée | 07.08.2021 | Leotar Trebinje | - | FK Tuzla City | 0:2 | ||||
| 5. Journée | 13.08.2021 | Široki Brijeg | - | Leotar Trebinje | 2:0 | ||||
| 6. Journée | 25.08.2021 | Leotar Trebinje | - | HŠK Posušje | 2:2 | ||||
| 7. Journée | 28.08.2021 | Velež Mostar | - | Leotar Trebinje | 2:1 | ||||
| 8. Journée | 11.09.2021 | Leotar Trebinje | - | Zrinjski Mostar | 0:1 |  |
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| 9. Journée | 17.09.2021 | FK Sarajevo | - | Leotar Trebinje | 0:1 | |
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| 10. Journée | 22.09.2021 | Leotar Trebinje | - | FK Rudar | 2:1 | ||||
| 12. Journée | 02.10.2021 | Leotar Trebinje | - | Radnik Bijeljina | 1:0 | ||||
| 13. Journée | 16.10.2021 | Leotar Trebinje | - | Borac Banja Luka | 1:1 | |
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| 15. Journée | 31.10.2021 | FK Tuzla City | - | Leotar Trebinje | 4:0 | ||||
| 16. Journée | 06.11.2021 | Leotar Trebinje | - | Široki Brijeg | 1:3 | ||||
| 17. Journée | 21.11.2021 | HŠK Posušje | - | Leotar Trebinje | 1:0 | |
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| 18. Journée | 27.11.2021 | Leotar Trebinje | - | Velež Mostar | 1:3 | |
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| 19. Journée | 03.12.2021 | Zrinjski Mostar | - | Leotar Trebinje | 6:2 |
Bosnie-Herzégovine