| 5. Journée | 02.03.2021 | Libertad | - | River Plate | 2:1 | ||||
| 7. Journée | 10.03.2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 8. Journée | 13.03.2021 | River Plate | - | Club Nacional | 0:0 |  |
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| 9. Journée | 22.03.2021 | Club Olimpia | - | River Plate | 5:1 | ||||
| 14. Journée | 04.05.2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Journée | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Journée | 16.05.2021 | River Plate | - | Cerro Porteño | 1:1 |
Paraguay