| 1. Journée | 26.02.2022 | Philadelphia Union | - | Minnesota United FC | 1:1 | ||||
| 2. Journée | 05.03.2022 | CF Montréal | - | Philadelphia Union | 1:2 | ||||
| 2. Journée | 13.03.2022 | Philadelphia Union | - | San Jose Earthquakes | 2:0 |  |
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| 2. Journée | 19.03.2022 | New York City FC | - | Philadelphia Union | 0:2 | ||||
| 3. Journée | 03.04.2022 | Philadelphia Union | - | Charlotte FC | 2:0 | ||||
| 3. Journée | 17.04.2022 | Toronto FC | - | Philadelphia Union | 2:1 | ||||
| 4. Journée | 08.05.2022 | Los Angeles FC | - | Philadelphia Union | 2:2 | |
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| 4. Journée | 15.05.2022 | Philadelphia Union | - | New York RB | 1:1 | ||||
| 4. Journée | 19.05.2022 | Philadelphia Union | - | Inter Miami CF | 0:0 | ||||
| 4. Journée | 23.05.2022 | Portland Timbers | - | Philadelphia Union | 0:2 |  |
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| 4. Journée | 29.05.2022 | New England Revolution | - | Philadelphia Union | 1:1 |
Brésil