| 1. Journée | 28.08.2021 | Alphense Boys [U21] | - | Roda JC Kerkrade [U21] | 3:1 |  |
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| 2. Journée | 11.09.2021 | Vitesse [U21] | - | Alphense Boys [U21] | 1:2 | ||||
| 3. Journée | 18.09.2021 | Alphense Boys [U21] | - | SBV Excelsior [U21] | 1:0 | ||||
| 4. Journée | 25.09.2021 | Willem II [U21] | - | Alphense Boys [U21] | 5:2 | ||||
| 6. Journée | 16.10.2021 | Alphense Boys [U21] | - | FC Emmen [U21] | 0:0 | ||||
| 7. Journée | 23.10.2021 | De Graafschap [U21] | - | Alphense Boys [U21] | 2:1 | ||||
| 8. Journée | 30.10.2021 | PEC Zwolle [U21] | - | Alphense Boys [U21] | 3:0 | ||||
| 9. Journée | 06.11.2021 | Alphense Boys [U21] | - | Willem II [U21] | 0:3 | ||||
| 10. Journée | 20.11.2021 | SBV Excelsior [U21] | - | Alphense Boys [U21] | 2:1 | ||||
| 12. Journée | 05.02.2022 | Roda JC Kerkrade [U21] | - | Alphense Boys [U21] | 2:2 | ||||
| 13. Journée | 12.02.2022 | Alphense Boys [U21] | - | De Graafschap [U21] | 1:3 |
Pays-Bas