| 1. Journée | 18.07.2021 | Luki-Energiya Velikiye Luki | - | Zenit St. Petersburg 2 | 3:3 |  |
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| 3. Journée | 01.08.2021 | Zenit St. Petersburg 2 | - | Zvezda St. Petersburg | 2:1 | ||||
| 6. Journée | 21.08.2021 | FK Krasava | - | Zenit St. Petersburg 2 | 6:0 |  |
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| 7. Journée | 28.08.2021 | Zenit St. Petersburg 2 | - | FK Chita | 4:0 | ||||
| 8. Journée | 04.09.2021 | FK Tver | - | Zenit St. Petersburg 2 | 2:2 | ||||
| 11. Journée | 18.09.2021 | Zenit St. Petersburg 2 | - | Baltika Kaliningrad 2 | 2:1 | |
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| 13. Journée | 30.09.2021 | Zvezda St. Petersburg | - | Zenit St. Petersburg 2 | 3:0 | |
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| 14. Journée | 04.10.2021 | Zenit St. Petersburg 2 | - | Dinamo St. Petersburg | 1:2 | |
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| 15. Journée | 10.10.2021 | FK Kairat Moskva | - | Zenit St. Petersburg 2 | 3:0 | ||||
| 16. Journée | 14.10.2021 | Zenit St. Petersburg 2 | - | FK Krasava | 1:0 | |
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| 17. Journée | 19.10.2021 | FK Chita | - | Zenit St. Petersburg 2 | 1:0 | ||||
| 18. Journée | 25.10.2021 | Zenit St. Petersburg 2 | - | FK Tver | 1:1 | ||||
| 19. Journée | 31.10.2021 | FK Leningradets | - | Zenit St. Petersburg 2 | 7:1 |
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