| 2. Journée | 17.04.2016 | Columbus Crew | - | New York City FC | 3:2 | ||||
| 2. Journée | 24.04.2016 | Columbus Crew | - | Houston Dynamo | 1:0 | ||||
| 2. Journée | 30.04.2016 | Seattle Sounders | - | Columbus Crew | 1:0 | ||||
| 3. Journée | 08.05.2016 | Columbus Crew | - | Impact de Montréal | 4:4 | ||||
| 3. Journée | 21.05.2016 | Toronto FC | - | Columbus Crew | 0:0 | ||||
| 3. Journée | 29.05.2016 | Columbus Crew | - | Real Salt Lake | 4:3 | ||||
| 4. Journée | 19.06.2016 | Columbus Crew | - | Impact de Montréal | 0:0 | ||||
| 5. Journée | 04.07.2016 | Sporting Kansas City | - | Columbus Crew | 3:2 | ||||
| 6. Journée | 21.08.2016 | New England Revolution | - | Columbus Crew | 0:2 | ||||
| 7. Journée | 18.09.2016 | Orlando City | - | Columbus Crew | 1:4 |
Guatemala