| 1. Journée | 15.02.2021 | Estudiantes | - | River Plate | 2:1 | ||||
| 2. Journée | 21.02.2021 | River Plate | - | Rosario Central | 3:0 | ||||
| 3. Journée | 28.02.2021 | Platense | - | River Plate | 0:1 | ||||
| 4. Journée | 09.03.2021 | River Plate | - | Argentinos Juniors | 0:1 | ||||
| 12. Journée | 02.05.2021 | Banfield | - | River Plate | 1:0 | ||||
| 13. Journée | 09.05.2021 | River Plate | - | Aldosivi | 4:1 |  |
Paraguay