| 1. Journée | 05.02.2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
| 2. Journée | 13.02.2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 4. Journée | 25.02.2022 | Sportivo Ameliano | - | General Caballero DJLM | 1:0 | ||||
| 6. Journée | 13.03.2022 | Guaraní | - | General Caballero DJLM | 3:1 |
Paraguay