| 1. Journée | 25.08.2012 | Defensor Sporting | - | Nacional | 2:2 |  |
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| 2. Journée | 01.09.2012 | Montevideo Wanderers | - | Defensor Sporting | 0:4 |  |
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| 3. Journée | 15.09.2012 | Defensor Sporting | - | Liverpool | 2:0 | ||||
| 4. Journée | 23.09.2012 | Progreso | - | Defensor Sporting | 1:4 | |
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| 5. Journée | 30.09.2012 | Defensor Sporting | - | Juventud de Las Piedras | 1:1 | ||||
| 6. Journée | 07.10.2012 | El Tanque Sisley | - | Defensor Sporting | 1:1 | ||||
| 7. Journée | 14.10.2012 | Defensor Sporting | - | Racing | 1:0 | ||||
| 8. Journée | 21.10.2012 | Defensor Sporting | - | Danubio | 3:1 | |
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| 11. Journée | 10.11.2012 | Fénix | - | Defensor Sporting | 1:3 | ||||
| 12. Journée | 17.11.2012 | Defensor Sporting | - | Bella Vista | 4:0 | |
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| 13. Journée | 24.11.2012 | River Plate | - | Defensor Sporting | 1:1 | |
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| 15. Journée | 08.12.2012 | Defensor Sporting | - | CA Cerro | 2:0 |
Uruguay
Italie