| Qualif. 2e tour | 17.10.2021 | AS Maniema Union | - | Mamelodi Sundowns | 2:2 | ||||
| Groupe A | 11.02.2022 | Mamelodi Sundowns | - | Al Hilal Omdurman | 1:0 | ||||
| Groupe A | 12.03.2022 | Mamelodi Sundowns | - | Al Ahly SC | 1:0 | ||||
| Quarts de finale | 16.04.2022 | Petro Atlético | - | Mamelodi Sundowns | 2:1 | ||||
| Quarts de finale | 23.04.2022 | Mamelodi Sundowns | - | Petro Atlético | 1:1 |
Slovaquie