| 1. Journée | 05.02.2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
| 2. Journée | 11.02.2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 4. Journée | 28.02.2022 | Tacuary | - | Libertad | 0:1 | ||||
| 5. Journée | 07.03.2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 7. Journée | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 11. Journée | 22.04.2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
| 12. Journée | 26.04.2022 | Tacuary | - | Resistencia SC | 3:1 |  |
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| 13. Journée | 30.04.2022 | 12 de Octubre de Itauguá | - | Tacuary | 2:0 | ||||
| 15. Journée | 11.05.2022 | Libertad | - | Tacuary | 3:0 | ||||
| 19. Journée | 20.06.2022 | Tacuary | - | Guaraní | 0:2 | ||||
| 20. Journée | 24.06.2022 | Guaireña FC | - | Tacuary | 0:0 |
Paraguay