| 2. Journée | 13.03.2022 | Philadelphia Union | - | San Jose Earthquakes | 2:0 |  |
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| 3. Journée | 03.04.2022 | San Jose Earthquakes | - | Austin FC | 2:2 | |
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| 3. Journée | 10.04.2022 | Houston Dynamo | - | San Jose Earthquakes | 4:3 | ||||
| 3. Journée | 16.04.2022 | San Jose Earthquakes | - | Nashville SC | 2:2 | ||||
| 4. Journée | 01.05.2022 | New York City FC | - | San Jose Earthquakes | 3:0 | ||||
| 4. Journée | 15.05.2022 | Vancouver Whitecaps | - | San Jose Earthquakes | 3:3 | ||||
| 5. Journée | 19.06.2022 | Real Salt Lake | - | San Jose Earthquakes | 2:0 | ||||
| 6. Journée | 10.07.2022 | Toronto FC | - | San Jose Earthquakes | 2:2 | ||||
| 6. Journée | 31.07.2022 | San Jose Earthquakes | - | Real Salt Lake | 2:2 |
Burkina Faso