| 1. Journée | 09.08.2021 | Honduras Progreso | - | Marathón | 1:2 | ||||
| 2. Journée | 13.08.2021 | Platense | - | Honduras Progreso | 1:1 |  |
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| 3. Journée | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 4. Journée | 22.08.2021 | Honduras Progreso | - | Victoria | 2:0 | ||||
| 5. Journée | 26.08.2021 | Olimpia | - | Honduras Progreso | 2:1 | ||||
| 6. Journée | 29.08.2021 | Honduras Progreso | - | Vida | 1:1 | |
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| 7. Journée | 05.09.2021 | Honduras Progreso | - | Motagua | 0:3 | ||||
| 8. Journée | 12.09.2021 | Real Sociedad | - | Honduras Progreso | 1:0 | |
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| 9. Journée | 16.09.2021 | Honduras Progreso | - | Real España | 1:1 |  |
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| 10. Journée | 20.09.2021 | Vida | - | Honduras Progreso | 1:0 | ||||
| 11. Journée | 23.09.2021 | Victoria | - | Honduras Progreso | 1:2 | ||||
| 12. Journée | 03.10.2021 | Honduras Progreso | - | Platense | 4:2 | ||||
| 13. Journée | 09.10.2021 | Marathón | - | Honduras Progreso | 2:1 |  |
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| 16. Journée | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 | |
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| 18. Journée | 10.11.2021 | Motagua | - | Honduras Progreso | 3:2 |
Honduras