| tour des 16 | 18.02.2022 | Motagua | - | Seattle Sounders | 0:0 | ||||
| tour des 16 | 25.02.2022 | Seattle Sounders | - | Motagua | 5:0 |  |
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| Demi-finales | 07.04.2022 | Seattle Sounders | - | New York City FC | 3:1 | |
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| Demi-finales | 14.04.2022 | New York City FC | - | Seattle Sounders | 1:1 | ||||
| Finale | 28.04.2022 | Pumas UNAM | - | Seattle Sounders | 2:2 | |
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| Finale | 05.05.2022 | Seattle Sounders | - | Pumas UNAM | 3:0 | |
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Uruguay
États-Unis