| 6. Journée | 14.08.2021 | Atlético Tucumán II | - | Aldosivi II | 3:2 |  |
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| 8. Journée | 24.08.2021 | Atlético Tucumán II | - | Independiente II | 0:0 | ||||
| 9. Journée | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 11. Journée | 10.09.2021 | Central Córdoba SdE II | - | Atlético Tucumán II | 1:1 | ||||
| 13. Journée | 24.09.2021 | Banfield II | - | Atlético Tucumán II | 1:0 | ||||
| 20. Journée | 05.11.2021 | Atlético Tucumán II | - | Racing Club II | 2:1 | ||||
| 22. Journée | 24.11.2021 | Atlético Tucumán II | - | Defensa y Justicia II | 4:1 | |
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| 25. Journée | 10.12.2021 | Atlético Tucumán II | - | River Plate II | 1:1 | |
Argentine