| 1. Journée | 17.02.2019 | Defensor Sporting | - | Peñarol | 0:1 | ||||
| 3. Journée | 03.03.2019 | Rampla Juniors | - | Defensor Sporting | 0:2 |  |
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| 4. Journée | 09.03.2019 | Defensor Sporting | - | Juventud de Las Piedras | 1:4 | ||||
| 6. Journée | 24.03.2019 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 7. Journée | 31.03.2019 | Racing | - | Defensor Sporting | 4:2 | ||||
| 9. Journée | 13.04.2019 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 10. Journée | 21.04.2019 | Defensor Sporting | - | Plaza Colonia | 4:1 | |
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| 11. Journée | 05.05.2019 | CA Cerro | - | Defensor Sporting | 0:2 | |
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| 12. Journée | 11.05.2019 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 13. Journée | 19.05.2019 | Nacional | - | Defensor Sporting | 1:0 | ||||
| 14. Journée | 25.05.2019 | Defensor Sporting | - | Fénix | 2:4 | ||||
| 15. Journée | 01.06.2019 | Progreso | - | Defensor Sporting | 0:3 |
Uruguay