| 1. Journée | 18.04.2021 | FC Dallas | - | Colorado Rapids | 0:0 | ||||
| 1. Journée | 25.04.2021 | Colorado Rapids | - | Austin FC | 1:3 | ||||
| 2. Journée | 16.05.2021 | Colorado Rapids | - | Houston Dynamo | 3:1 | ||||
| 2. Journée | 23.05.2021 | Los Angeles FC | - | Colorado Rapids | 2:1 | ||||
| 2. Journée | 30.05.2021 | Colorado Rapids | - | FC Dallas | 3:0 | ||||
| 3. Journée | 20.06.2021 | FC Cincinnati | - | Colorado Rapids | 0:2 | ||||
| 3. Journée | 24.06.2021 | Sporting Kansas City | - | Colorado Rapids | 3:1 | ||||
| 4. Journée | 08.07.2021 | Colorado Rapids | - | Minnesota United FC | 2:0 | ||||
| 4. Journée | 18.07.2021 | Colorado Rapids | - | San Jose Earthquakes | 1:1 | ||||
| 4. Journée | 22.07.2021 | Colorado Rapids | - | FC Dallas | 2:0 | ||||
| 4. Journée | 25.07.2021 | Real Salt Lake | - | Colorado Rapids | 3:0 |
France