| 6. Journée | 26.09.2021 | Lazio Roma | - | AS Roma | 3:2 | ||||
| 7. Journée | 03.10.2021 | AS Roma | - | Empoli FC | 2:0 | ||||
| 12. Journée | 07.11.2021 | Venezia FC | - | AS Roma | 3:2 | ||||
| 26. Journée | 19.02.2022 | AS Roma | - | Hellas Verona | 2:2 | ||||
| 27. Journée | 27.02.2022 | Spezia Calcio | - | AS Roma | 0:1 | ||||
| 28. Journée | 05.03.2022 | AS Roma | - | Atalanta | 1:0 | ||||
| 29. Journée | 13.03.2022 | Udinese Calcio | - | AS Roma | 1:1 | ||||
| 30. Journée | 20.03.2022 | AS Roma | - | Lazio Roma | 3:0 |  |
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| 31. Journée | 03.04.2022 | Sampdoria | - | AS Roma | 0:1 | ||||
| 32. Journée | 10.04.2022 | AS Roma | - | US Salernitana 1919 | 2:1 | ||||
| 33. Journée | 18.04.2022 | SSC Napoli | - | AS Roma | 1:1 | ||||
| 34. Journée | 23.04.2022 | Inter | - | AS Roma | 3:1 | ||||
| 35. Journée | 01.05.2022 | AS Roma | - | Bologna FC | 0:0 | ||||
| 36. Journée | 09.05.2022 | ACF Fiorentina | - | AS Roma | 2:0 | ||||
| 37. Journée | 14.05.2022 | AS Roma | - | Venezia FC | 1:1 | ||||
| 38. Journée | 20.05.2022 | Torino FC | - | AS Roma | 0:3 |
Italie