| 1. Journée | 03.07.2022 | CD Guabirá | - | Always Ready | 0:1 | ||||
| 2. Journée | 07.07.2022 | Club Aurora | - | CD Guabirá | 1:0 |  |
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| 3. Journée | 12.07.2022 | CD Guabirá | - | Universitario de Sucre | 5:0 | |
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| 4. Journée | 16.07.2022 | Jorge Wilstermann | - | CD Guabirá | 2:2 | ||||
| 5. Journée | 23.07.2022 | CD Guabirá | - | Nacional Potosí | 2:1 | ||||
| 14. Journée | 31.08.2022 | The Strongest | - | CD Guabirá | 2:3 | ||||
| 15. Journée | 04.09.2022 | CD Guabirá | - | Real Santa Cruz | 2:1 | ||||
| 16. Journée | 07.09.2022 | Always Ready | - | CD Guabirá | 2:1 | |
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| 19. Journée | 01.10.2022 | CD Guabirá | - | Jorge Wilstermann | 1:1 | ||||
| 20. Journée | 05.10.2022 | Nacional Potosí | - | CD Guabirá | 3:1 |
Paraguay