| 1. Journée | 12.03.2022 | Twente/Heracles [U21] | - | SBV Excelsior [U21] | 2:1 |  |
|||
| 2. Journée | 19.03.2022 | FC Den Bosch [U21] | - | Twente/Heracles [U21] | 3:2 | ||||
| 4. Journée | 09.04.2022 | Twente/Heracles [U21] | - | Go Ahead Eagles [U21] | 1:3 | |
|||
| 5. Journée | 23.04.2022 | De Graafschap [U21] | - | Twente/Heracles [U21] | 1:1 | |
|||
| 6. Journée | 07.05.2022 | Twente/Heracles [U21] | - | FC Emmen [U21] | 1:2 | |
|||
| 7. Journée | 13.05.2022 | sc Heerenveen [U21] | - | Twente/Heracles [U21] | 1:4 |
Pays-Bas