| 1. Journée | 06.08.2022 | Tottenham Hotspur | - | Southampton FC | 4:1 | ||||
| 2. Journée | 13.08.2022 | Southampton FC | - | Leeds United | 2:2 | ||||
| 3. Journée | 20.08.2022 | Leicester City | - | Southampton FC | 1:2 | ||||
| 4. Journée | 27.08.2022 | Southampton FC | - | Manchester United | 0:1 | ||||
| 5. Journée | 30.08.2022 | Southampton FC | - | Chelsea FC | 2:1 | ||||
| 6. Journée | 03.09.2022 | Wolverhampton Wanderers | - | Southampton FC | 1:0 | ||||
| 8. Journée | 16.09.2022 | Aston Villa | - | Southampton FC | 1:0 | ||||
| 10. Journée | 08.10.2022 | Manchester City | - | Southampton FC | 4:0 | ||||
| 12. Journée | 19.10.2022 | AFC Bournemouth | - | Southampton FC | 0:1 | ||||
| 14. Journée | 29.10.2022 | Crystal Palace | - | Southampton FC | 1:0 | ||||
| 17. Journée | 26.12.2022 | Southampton FC | - | Brighton & Hove Albion | 1:3 | ||||
| 21. Journée | 21.01.2023 | Southampton FC | - | Aston Villa | 0:1 | ||||
| 30. Journée | 08.04.2023 | Southampton FC | - | Manchester City | 1:4 | ||||
| 31. Journée | 15.04.2023 | Southampton FC | - | Crystal Palace | 0:2 | ||||
| 34. Journée | 30.04.2023 | Newcastle United | - | Southampton FC | 3:1 | ||||
| 36. Journée | 13.05.2023 | Southampton FC | - | Fulham FC | 0:2 |  |
Mali