| 1. Journée | 16.07.2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Journée | 23.07.2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 4. Journée | 30.07.2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 |  |
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| 5. Journée | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Journée | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 8. Journée | 24.08.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Journée | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 11. Journée | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 14. Journée | 01.10.2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 | ||||
| 15. Journée | 08.10.2021 | Newell's Old Boys II | - | Vélez Sarsfield II | 0:0 | ||||
| 20. Journée | 05.11.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 |
Argentine