| 3. Journée | 17.08.2021 | Colchester United | - | Mansfield Town | 1:1 | ||||
| 4. Journée | 21.08.2021 | Oldham Athletic | - | Colchester United | 1:2 | ||||
| 5. Journée | 27.08.2021 | Rochdale AFC | - | Colchester United | 1:1 |  |
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| 14. Journée | 23.10.2021 | Port Vale FC | - | Colchester United | 3:0 | ||||
| 6. Journée | 26.10.2021 | Colchester United | - | Sutton United | 1:3 | ||||
| 15. Journée | 30.10.2021 | Colchester United | - | Scunthorpe United | 2:1 | ||||
| 27. Journée | 15.01.2022 | Colchester United | - | Barrow AFC | 0:2 | ||||
| 24. Journée | 18.01.2022 | Sutton United | - | Colchester United | 3:2 | ||||
| 30. Journée | 05.02.2022 | Leyton Orient | - | Colchester United | 0:1 | |
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| 36. Journée | 12.03.2022 | Scunthorpe United | - | Colchester United | 1:3 | ||||
| 40. Journée | 02.04.2022 | Harrogate Town | - | Colchester United | 1:2 | ||||
| 43. Journée | 18.04.2022 | Colchester United | - | Bradford City | 3:0 |
Angleterre