| 1. Journée | 12.08.2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 3. Journée | 11.09.2021 | Gżira United | - | Sliema Wanderers | 1:1 |  |
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| 4. Journée | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 | |
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| 6. Journée | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 8. Journée | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | |
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| 10. Journée | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
| 11. Journée | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 |
Portugal