| 1er tour | 03.09.2010 | Club Olimpia | - | Defensor Sporting | 1:1 | ||||
| 2e tour | 17.09.2010 | Defensor Sporting | - | Sport Huancayo | 9:0 |  |
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| 2e tour | 22.09.2010 | Sport Huancayo | - | Defensor Sporting | 2:0 | ||||
| tour des 16 | 29.09.2010 | Defensor Sporting | - | Independiente | 1:0 | ||||
| tour des 16 | 20.10.2010 | Independiente | - | Defensor Sporting | 4:2 |
Uruguay