| 2. Journée | 21.09.1980 | AS Roma | - | Brescia Calcio | 1:0 | ||||
| 3. Journée | 28.09.1980 | Bologna FC | - | AS Roma | 1:1 | ||||
| 5. Journée | 19.10.1980 | SSC Napoli | - | AS Roma | 4:0 | ||||
| 6. Journée | 26.10.1980 | Inter | - | AS Roma | 2:4 | ||||
| 11. Journée | 21.12.1980 | AS Roma | - | Ascoli Calcio | 4:1 | ||||
| 16. Journée | 08.02.1981 | AS Roma | - | Como Calcio | 1:1 | ||||
| 19. Journée | 01.03.1981 | Torino FC | - | AS Roma | 0:2 | ||||
| 20. Journée | 08.03.1981 | AS Roma | - | SSC Napoli | 1:1 | ||||
| 21. Journée | 15.03.1981 | AS Roma | - | Inter | 1:0 | ||||
| 22. Journée | 22.03.1981 | US Catanzaro | - | AS Roma | 1:1 | ||||
| 24. Journée | 05.04.1981 | Udinese Calcio | - | AS Roma | 0:2 | ||||
| 29. Journée | 17.05.1981 | AS Roma | - | AC Pistoiese | 1:0 |
Italie