| 1. Journée | 16.08.2021 | Newcastle United U23 | - | Reading FC U23 | 1:1 |  |
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| 2. Journée | 23.08.2021 | Reading FC U23 | - | Wolverhampton Wanderers U23 | 3:0 | |
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| 3. Journée | 29.08.2021 | Stoke City U23 | - | Reading FC U23 | 1:2 | ||||
| 4. Journée | 12.09.2021 | Reading FC U23 | - | Nottingham Forest U23 | 0:2 | |
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| 5. Journée | 20.09.2021 | Reading FC U23 | - | Norwich City U23 | 3:3 |  |
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| 6. Journée | 27.09.2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | ||||
| 7. Journée | 04.10.2021 | Reading FC U23 | - | Birmingham City U23 | 1:1 | |
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| 12. Journée | 22.11.2021 | West Bromwich Albion U23 | - | Reading FC U23 | 1:1 | ||||
| 13. Journée | 29.11.2021 | Reading FC U23 | - | Middlesbrough FC U23 | 2:1 | ||||
| 14. Journée | 03.12.2021 | Norwich City U23 | - | Reading FC U23 | 5:2 | ||||
| 18. Journée | 24.01.2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 19. Journée | 07.02.2022 | Reading FC U23 | - | Stoke City U23 | 1:1 |
Angleterre