| 1. Journée | 28.08.2021 | FC Groningen [U21] | - | NEC Nijmegen [U21] | 2:1 |  |
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| 2. Journée | 11.09.2021 | Almere City FC [U21] | - | FC Groningen [U21] | 1:2 | ||||
| 3. Journée | 18.09.2021 | FC Groningen [U21] | - | Feyenoord [U21] | 2:1 | ||||
| 7. Journée | 23.10.2021 | FC Groningen [U21] | - | ADO Den Haag [U21] | 2:1 | ||||
| 10. Journée | 20.11.2021 | ADO Den Haag [U21] | - | FC Groningen [U21] | 4:2 | ||||
| 11. Journée | 27.11.2021 | FC Groningen [U21] | - | Almere City FC [U21] | 3:0 | ||||
| 14. Journée | 18.12.2021 | FC Groningen [U21] | - | Twente/Heracles [U21] | 6:1 |  |
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