| 1. Journée | 09.01.2021 | Club Tijuana | - | Pumas UNAM | 0:0 | ||||
| 2. Journée | 16.01.2021 | FC Juárez | - | Club Tijuana | 0:0 | ||||
| 3. Journée | 23.01.2021 | Puebla FC | - | Club Tijuana | 0:1 |  |
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| 4. Journée | 31.01.2021 | Club Tijuana | - | Deportivo Toluca | 3:2 |  |
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| 5. Journée | 05.02.2021 | Atlético San Luis | - | Club Tijuana | 2:2 | ||||
| 6. Journée | 13.02.2021 | Club Tijuana | - | Club León | 2:0 | |
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| 7. Journée | 22.02.2021 | UANL Tigres | - | Club Tijuana | 3:2 | ||||
| 8. Journée | 01.03.2021 | CF Monterrey | - | Club Tijuana | 1:1 | |
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| 9. Journée | 04.03.2021 | Club Tijuana | - | CF América | 0:2 | ||||
| 10. Journée | 09.03.2021 | CF Pachuca | - | Club Tijuana | 2:1 | ||||
| 11. Journée | 14.03.2021 | Club Tijuana | - | Santos Laguna | 0:1 | ||||
| 12. Journée | 21.03.2021 | Club Tijuana | - | Gallos Blancos | 3:1 | |
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| 13. Journée | 04.04.2021 | Atlas Guadalajara | - | Club Tijuana | 1:0 | ||||
| 14. Journée | 12.04.2021 | Club Tijuana | - | Mazatlán FC | 2:3 | |
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| 15. Journée | 18.04.2021 | Deportivo Guadalajara | - | Club Tijuana | 2:0 | ||||
| 16. Journée | 24.04.2021 | Club Tijuana | - | Club Necaxa | 1:0 | ||||
| 17. Journée | 02.05.2021 | Cruz Azul | - | Club Tijuana | 1:1 |
Colombie