| 1. Journée | 01.08.2022 | Liverpool | - | Defensor Sporting | 1:3 |  |
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| 3. Journée | 14.08.2022 | Montevideo City Torque | - | Defensor Sporting | 0:2 | ||||
| 6. Journée | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 | |
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| 5. Journée | 28.08.2022 | Plaza Colonia | - | Defensor Sporting | 0:1 | ||||
| 4. Journée | 03.09.2022 | Defensor Sporting | - | Montevideo Wanderers | 1:0 | |
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| 7. Journée | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 14. Journée | 15.10.2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 |
Uruguay