| 1. Journée | 22.07.2018 | Atenas | - | Defensor Sporting | 2:5 | ||||
| 2. Journée | 28.07.2018 | Defensor Sporting | - | Danubio | 1:2 | ||||
| 3. Journée | 05.08.2018 | Torque | - | Defensor Sporting | 0:0 | ||||
| 4. Journée | 12.08.2018 | Defensor Sporting | - | Rampla Juniors | 2:2 |  |
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| 6. Journée | 26.08.2018 | Defensor Sporting | - | Nacional | 2:0 | ||||
| 7. Journée | 02.09.2018 | Progreso | - | Defensor Sporting | 0:0 | ||||
| 8. Journée | 08.09.2018 | CA Cerro | - | Defensor Sporting | 1:1 | ||||
| 9. Journée | 16.09.2018 | Defensor Sporting | - | Racing | 2:1 | ||||
| 10. Journée | 23.09.2018 | River Plate | - | Defensor Sporting | 3:2 | |
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| 11. Journée | 06.10.2018 | Defensor Sporting | - | Montevideo Wanderers | 3:0 | ||||
| 12. Journée | 14.10.2018 | Liverpool | - | Defensor Sporting | 2:1 | ||||
| 14. Journée | 28.10.2018 | Boston River | - | Defensor Sporting | 3:1 | ||||
| 15. Journée | 04.11.2018 | Defensor Sporting | - | Peñarol | 1:2 | |
Uruguay