| 1. Journée | 07.02.2016 | Sud América | - | Defensor Sporting | 2:0 | ||||
| 2. Journée | 14.02.2016 | Defensor Sporting | - | Racing | 1:3 | ||||
| 3. Journée | 22.02.2016 | Peñarol | - | Defensor Sporting | 5:1 | ||||
| 4. Journée | 28.02.2016 | Defensor Sporting | - | Danubio | 3:2 | ||||
| 5. Journée | 06.03.2016 | Rentistas | - | Defensor Sporting | 0:1 |  |
|||
| 7. Journée | 02.04.2016 | Villa Teresa | - | Defensor Sporting | 2:2 | ||||
| 8. Journée | 11.04.2016 | Defensor Sporting | - | Nacional | 2:4 | |
|||
| 9. Journée | 23.04.2016 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | |
|||
| 10. Journée | 30.04.2016 | Defensor Sporting | - | Plaza Colonia | 1:1 | ||||
| 11. Journée | 08.05.2016 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | |
|||
| 12. Journée | 14.05.2016 | Defensor Sporting | - | CA Cerro | 1:0 | ||||
| 13. Journée | 22.05.2016 | El Tanque Sisley | - | Defensor Sporting | 5:6 | ||||
| 14. Journée | 29.05.2016 | River Plate | - | Defensor Sporting | 1:2 | ||||
| 15. Journée | 05.06.2016 | Defensor Sporting | - | Fénix | 1:0 |
Uruguay