| 4. Journée | 02.08.2021 | Patronato de Paraná | - | Newell's Old Boys | 0:0 | ||||
| 5. Journée | 07.08.2021 | Newell's Old Boys | - | Platense | 1:0 | ||||
| 7. Journée | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Journée | 25.08.2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 |  |
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| 9. Journée | 30.08.2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Journée | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 13. Journée | 28.09.2021 | Newell's Old Boys | - | Huracán | 0:1 | ||||
| 14. Journée | 02.10.2021 | Godoy Cruz | - | Newell's Old Boys | 2:2 | |
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| 15. Journée | 09.10.2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 | |
Argentine