| 1. Journée | 23.01.2010 | Atenas | - | Defensor Sporting | 3:1 | ||||
| 2. Journée | 31.01.2010 | Defensor Sporting | - | Danubio | 0:1 | ||||
| 3. Journée | 06.02.2010 | Nacional | - | Defensor Sporting | 0:1 |  |
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| 4. Journée | 13.02.2010 | Defensor Sporting | - | Central Español | 3:4 | ||||
| 5. Journée | 21.02.2010 | Fénix | - | Defensor Sporting | 3:0 | ||||
| 6. Journée | 27.02.2010 | Defensor Sporting | - | Rampla Juniors | 2:1 | ||||
| 8. Journée | 13.03.2010 | Cerro Largo | - | Defensor Sporting | 1:3 | |
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| 10. Journée | 28.03.2010 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 11. Journée | 03.04.2010 | Racing | - | Defensor Sporting | 3:3 | ||||
| 12. Journée | 09.04.2010 | Defensor Sporting | - | CA Cerro | 1:0 | ||||
| 13. Journée | 17.04.2010 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 14. Journée | 25.04.2010 | Defensor Sporting | - | Montevideo Wanderers | 2:0 | ||||
| 15. Journée | 02.05.2010 | Liverpool | - | Defensor Sporting | 3:0 |
Uruguay