| 5. Journée | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 | ||||
| 6. Journée | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 8. Journée | 24.08.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 9. Journée | 30.08.2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 |  |
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| 10. Journée | 03.09.2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Journée | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Journée | 17.09.2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 13. Journée | 24.09.2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 16. Journée | 14.10.2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 20. Journée | 05.11.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 22. Journée | 24.11.2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Journée | 30.11.2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Journée | 06.12.2021 | Newell's Old Boys II | - | Banfield II | 2:0 | ||||
| 25. Journée | 10.12.2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentine