| 2. Journée | 22.05.2021 | Cerro Largo | - | Cerrito | 3:1 |  |
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| 3. Journée | 29.05.2021 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 1. Journée | 03.06.2021 | Nacional | - | Cerro Largo | 1:2 | ||||
| 4. Journée | 06.06.2021 | Cerro Largo | - | River Plate | 2:4 | ||||
| 5. Journée | 13.06.2021 | Deportivo Maldonado | - | Cerro Largo | 2:1 | |
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| 6. Journée | 19.06.2021 | Progreso | - | Cerro Largo | 0:0 | |
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| 7. Journée | 22.06.2021 | Cerro Largo | - | Sud América | 2:1 | ||||
| 8. Journée | 28.06.2021 | Plaza Colonia | - | Cerro Largo | 1:1 | ||||
| 9. Journée | 03.07.2021 | Cerro Largo | - | Fénix | 1:2 | ||||
| 10. Journée | 11.07.2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 11. Journée | 17.07.2021 | Cerro Largo | - | Montevideo Wanderers | 2:0 | ||||
| 12. Journée | 30.07.2021 | Rentistas | - | Cerro Largo | 1:3 | ||||
| 13. Journée | 06.08.2021 | Cerro Largo | - | Peñarol | 0:1 |
Uruguay